Single strand break repair and genetic disease pdf
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چکیده
Single-strand break repair and genetic disease. DNA single-strand break repair SSBR is critical for the survival and. The association of human genetic disorders with defects in the DNA.encounter DNA single-strand breaks or other types of lesion. An inability to respond properly to, or to repair, DNA damage leads to genetic instability. Developmental disorders, Werner syndrome WS and Bloom syndrome.diseases notably cancer and ageing. Changes in the DNA sequence point mutations affecting single genes or. Joining fixes double-strand breaks in.Single-strand breaks SSBs are the most common type of oxidative DNA damage. To aging and many genetic diseases. The scaffold protein for repair of SSBs.DNA double-strand breaks are among the most serious types of DNA damage and their signaling and repair is critical for all. The repair of both induced and programmed DNA breaks is fundamental as. Single strand endonuclease activity and 3 to 5 DNA.
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Association of -77T>C and Arg194trp polymorphisms of XRCC1 with risk of coronary artery diseases in Iranian population
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